Spiralin is the most abundant protein of several species of spiroplasmas, helical, motile bacteria pathogenic for arthropods and plants. This amphiphilic protein is anchored to
PAPERS
Vtc5, a novel subunit of the vacuolar transporter chaperone complex, regulates polyphosphate synthesis and phosphate homeostasis in yeast.
SPX domains control phosphate homeostasis in eukaryotes. Ten genes in yeast encode SPX-containing proteins, among which YDR089W is the only one of unknown function. Here,
Organelle size control – increasing vacuole content activates SNAREs to augment organelle volume through homotypic fusion
Cells control the size of their compartments relative to cell volume, but there is also size control within each organelle. Yeast vacuoles neither burst nor
A modular tethering complex for endosomal recycling.
How proteins migrate through the interconnected organelles of the endolysosomal system is poorly understood. A piece of the puzzle has been added with the identification
NEWS FROM THE SAIARDI LAB
Science outreach: Science is not a democracy.
Adolfo Saiardi talks at a TEDx conference in Cosenza explaining why Science is not a democracy. See Online TEDx TV or Youtube.
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling
Miranda S.C. Wilson and Adolfo Saiardi. Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective
Abstract Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into
Protein pyrophosphorylation: moving forward.
Protein pyrophosphorylation: moving forward lipitor generic. Comment on: Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport Genetic ablation of inositol pyrophosphate synthesis
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels Collaborative work with the lab of S. Shears. The HCT116 cell
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer’s disease
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer’s disease Maintenance of electric potential and