Phosphate homeostasis and energy metabolism in eukaryotes

My interest for phosphate homeostasis and the function of highly phosphorylated molecules (inositol polyphosphateand inorganic polyphosphate) started during my first postdoc when I was working on membrane trafficking at the University of Lausanne (Switzerland)(see below). I then decided to move to a lab with theoretical and experimental expertise in phosphate homeostasis and energy metabolism. I am now working in the lab of Adolfo Saiardi at University College London (MRC LMCB).

My research brings together metabolism and signalling and focuses on how eukaryotic cells sense intracellular phosphate, how they deal with phosphate stores, and how they regulate the size of the different phosphate pools (inositol polyphosphate, inorganic polyphosphate, nucleotides pool, free phosphate). I am using two model systems to tackle the problem: yeast (Saccharomyces cerevisiae, Schizosaccharomyces pombe) and the social amoebaDictyostelium discoideum.


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